Background: This study focuses on the histopathological characteristics of benign and potentially malignant lesions of the gallbladder, with a specific emphasis on the efficacy of cholecystectomy as a secondary preventive measure in specific clinical contexts. The aim is to contribute to the development of improved preventive and therapeutic approaches.Methodology: This research study employed a hybrid approach of retrospective and prospective data analysis on cholecystitis during the year 2023. Various variables were analyzed to explore their associations with clinical outcomes.Results: The study included 63 patients with no statistically significant differences in age between male and female patients. Analysis of the length, width, and thickness of the gallbladder wall did not reveal statistically significant differences (p>0.05). Correlation analysis showed weak connections between age and gallbladder characteristics. The average recovery time was 4.46 days, and the duration of hospitalization positively correlated with age (p<0.001). Regression analysis indicated an association between symptoms and age with the duration of hospitalization (p=0.015, p<0.001). Logistic regression demonstrated an accuracy of 61.9%, with high precision in predicting stays longer than 3 days. Chi-square tests confirmed statistically significant differences in histopathological diagnoses related to comorbidities (p=0.021).Conclusion: Gender-specific approaches in postoperative treatment of patients with gallbladder issues highlight significant differences in patient characteristics, while the analysis of comorbidities reveals a connection between hypertension and pathological changes in the gallbladder.

In search for a novel non-steroidal anti-inflammatory drug (NSAID), we assessed the anti-inflammatory effects of Porphyra tenera extract (PTE) derived from Porphyra tenera, using a carrageenan (CA)-induced paw edema model. Four-week-old male Sprague-Dawley rats (weight = 80–100 g) were acclimatized to the laboratory for 1 week. Twenty-five rats were randomly divided into five groups of five. PTE was dissolved in pure water and orally administered at a dose of 1.0 or 0.3 g kg-1day-1 for 4 consecutive days. DEXA was utilized as a positive control. To induce acute phase inflammation in the right hind paw, rats were subcutaneously injected with a 1% solution of CA with saline (0.1 mL/animal) 1 h after vehicle or PTE treatment. The volumes of paws were determined up to 4 h after injection (intervals of 1 h). The paw volumes were measured volumetrically using a plethysmometer. As a result, an anti-edema effect of PTE was observed. Administration of 0.3 and 1.0 g/kg lyophilized PTE on 4 consecutive days significantly inhibited CA-induced increases in skin thickness and inflammatory cell infiltration in ventrum and dorsum pedis skin. Notably, our results demonstrated that 0.3 and 1.0 g/kg PTE effectively suppressed edematous inflammation by suppressing the key mediators, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Furthermore, our hepatoprotective effective evaluation showed low toxicity indicating the safeness of PTE as a drug potent, and our UPLC indicated β-carotene, lutein, and chlorogenic acid as the key compounds that facilitate anti-inflammation. Our results demonstrated the anti-inflammatory effects of PTE on the paw tissues of rats. We believe that PTE is an outstanding candidate for a novel NSAID. Through our preclinical trial based on rats, we were able to assess and collect important data for the basis of elucidating the underlying molecular mechanisms in natural products. We strongly discuss the necessity of further preclinical trials and research to develop safer and more effective natural-based drugs.

Tendering situations have shown deficiencies in guidelines for pricing and appreciating the projects, leading to corrupt activities of officials involved, poor workmanship, and unjustifiably high prices, among others. The paper develops a mathematical models that is easy to apply, in setting preliminary guidelines for setting standard on the price and value of the projects. A mathematical theorem and a lemma are also developed and proved to confirm the mathematical optimization, which serves as preliminary optimization for the tendering process. Cost savings and value addition are integrated in the process of using the model. Project price/value optimization occurs in the model when negotiation and negotiation guidelines are incorporated in the model. The model encourages involving the reputable tenderers in the competition and elimination of disreputable ones, and discourages compromises on value and quality. In closing, paper recommends use of the mathematical optimization as the basis for effecting the ultimate costing/value optimization for the tendering and the project.

company and its environment. The Cloud Computing is the major support provider for data centre in modern multi-tenant requirements. The development in the data management forces us to support the data centres for efficient and effective handling of data under modern connectivity infrastructure environment. The developments in cloud computing paradigm confirm the need of faster and efficient performance evaluation facilities for Data centres and its management. \nThe data centre should need enough resources such as storage capacity, managing software(s), additional capabilities such as optimization of storage, user requests. In a multi-tenant platform it demands rules and facilities on how we manage our data centre with operational management tasks. The advanced modeling of data does not feasible due to nature of data centre components such as different types of cloud servers, diversity of user requests, feasible storage capabilities in a multi-tenant province.\nWe proposed a new mechanism to overcome these performance problems and to aim for optimize their performance; we can achieve this goal with help of queuing theory which directly deals the performance and its issues and gives solutions.\nIn this paper, we proposed model called Multi-tenant Queue model focusing on the major performance metrics such as Transaction workload, internal response time, and effective utilization of resources. Calculation of Workload trace, on demand resource serving with no waiting time, a priori reserve of the resources in advance, no. of users as metrics considered for data performance under data centre. \nThe performance measurements are facilitated with Automated Workload Reports (AWRs) with flow graphs under Oracle Performance and tuning makes use ADDT for optimization data storage and retrievals for data centers to provide a breed of computers (micro data centre) powered by a smart cloud intelligent systems.

The purpose of this paper is to adapt Technology Acceptance Model (TAM), which is one of the models for adopting technological products, into technological product purchase behavior of consumer, and to test the moderator effects of technology readiness, the direct effects of which were examined in the previous studies, through the model. In order to test the relations included in the model Hierarchical Regression Test were conducted. As a result, the moderator effects showed that as the consumers’ insecurity towards a technological product and their discomfort in using the product increase, the effect of brand credibility on both perceived usefulness and perceived ease of use decreases.

The objective of this paper was to explore the relationship among conflict management, personality types and emotions. Conflict management is one of the key behaviors of an organization. Since it is investigated that everyone has a unique personality, so possibly to handle a conflict-based situation would also differ. The other main feature identified in this study was emotions. The current study aims to identify the relationship of personality and emotions with conflict-management patterns within hoteliers in Pakistan. Thus the present study carries the selection of two independent variables personality types specifically type A and emotions in relation with conflict management being the dependant variable. The sample of research consisted of fifteen major hotels in Pakistan comprising 290 employees as total. To fulfill the research purpose, Self-report structured and referenced questionnaires were used to assess the research variables. When personality types and conflict management was assessed, significant interaction was found. Emotions were found to have both positive and negative effect on conflict management. A series of regression analyses as well as correlation analysis were carried out in the research. A range of different approaches to explore these issues such as how different personality types are related with conflict management and how emotions (either positive or negative) play their important role in handling conflicts are discussed. Furthermore, limitations and recommendations are also being discussed that influence the relationship of conflict management, personality types and emotions of hoteliers differently.

Samanian made a wasting state for governing the samanian territory and professional administrators by a mixture of official customs of samani era and Islamic regulations could set up a well official system which in a short time could reach to promotions. The aim of present study is analyzing one the most important governing systems in Iran it means Samanian era. This article is made of library system and by providing fishes from the sources.

This research highlights the significance of preventing, finding out and treating diabetes mellitus (DM) from early stages of on set. The late finding of diabetes mellitus leads to both medical and economic losses. The treatment of the complications of the diabetic disease raises the costs of the care and the losses due to patient missing from work cannot be neglected. The expenses with diabetes mellitus have constantly increased everywhere in the world. The highest costs for a diabetic patient raised to 13,243 USD/patient/year, in 2002, in the USA – the highest ever recorded costs of this disease. The estimations made by International Diabetes Federation show that, in 2012, the cost for diabetic patients care reached 471 billion USD, in the world, and 138.8 billion USD, in Europe. A study carried out in Europe in 2008, showed that hospitalization costs represent almost 60% of the total costs of diabetes mellitus treatment, outpatient care costs 18.5% and drug therapy represents 21.7%. In Romania, the treatment of diabetes mellitus is free of charge. The funds allotted by the Ministry of Health for the Diabetes Programe in the time interval 1999-2012 increased 25 times, but Romania ranks among the top ten countries with diabetes cases in Europe.

In order to better understand how to prevent enzymatic greenning, it is important to\nunderstand kinetic properties of polyphenol oxidase. vegetable markets projected for the\nfuture will not occur if enzymatic greenning is not understood and controlled. We\ninvestigated the effect of SDS on the rate of catechol oxidation by wild pears partial\npurified PPO. PPO activity increased with increasing SDS concentration. The most\neffective concentration of SDS was 0.9 and 1 mM in according to pH and type of\nsubstrate, where the measured activity was 782 and 3200 units/mg.protein at pH 5 and\n380 and 1100 unit/mg.protei.n at pH 7 for catechol and pyrogallol, respectively at 1 mM\nSDS. The activation of pears PPO increased linearly with the SDS concentration up to 1\nmM and decreased thereafter. The activity of pear PPO was also enhanced 2.6-fold by\nexposure to SDS at pH 5.0 in presence of catechol, 3.7-fold by exposure to SDS at pH\n5.0 in presence of pyrogallol, 1.7-fold by exposure to SDS at pH 7 in presence of catechol\nand 1.7-fold by exposure to SDS at pH 5 in presence of pyrogallol. SDS has activating\neffect on polyphenol oxidase in presence of both dihydroxy and trihydroxy phenols, So\nthat, this activating effect at pH 5 is more than activating effect at pH 7.

Abstract:\nThe vast and growing need of society to the building and housing has raised the necessity of using construction systems and new construction materials in order to accelerate construction operation, reduce construction cost, increase quality and also retrofitting and strengthening buildings resistant against earthquake more than before.Due to the relatively vast geographical area of the developing country of Iran, and given the rapid burgeoning population and growing requirements to mass housing production, common and traditional construction methods utilization cannot meet the housing requests. So, application of modern technologies and/or construction methods by using industrial production methods is the proper response for the challenges facing the building industry of the country. (Golabchi, Mahmoud, 2010)