Evolutionary algorithms are a part of metaheuristics and commonly used for optimization, but very few researches about these algorithms have been conducted on cryptographic systems’ security. The Symmetric Evolutionary Ciphering (SEC) is one of these, it transforms the encryption issue into a combinatorial optimization problem and uses evolutionary algorithms to solve it.\n In this paper, we present a combination of our original system SEC and a new subdivision process which we are called “Break-Down Process”. This later is applied to the cipher text obtained by the SEC system to reach equilibrium the characters’ appearance frequencies. Thus, our main objective of this combination is to change the appearance frequencies of plaintext to end the frequency analysis attack. \nTo put our new system to the proof, we have selected texts with different sizes and compared the results of the appearance frequency of the cipher text once obtained by the SEC system without the new break-down process and another time with this later. The final solution of the system gives excellent results and proves the robustness of this work. Furthermore, the key generated by this system is so important: first; because it is a session key and then it’s so large to be broken. Reason why, the resistance of our new system will be increased against the brute force attack also

The research is a meta-analysis that circumscribes General Communication Science (Axis Communication Philosophy). The thinking platform has two principled pillars:\n i) that discourse has three “main dimensions”: “language use”, “communication of beliefs (cognition)”, and “interaction in situations”; as a “standard principle” (Van Dijk, 1997a, 1997b). \n ii) that, as a written language form of communication, the philosophy is a communicational cognition discourse.\n The inquiry is ranged among what it is called the dynamics of the reshaping conceptual standard-matrix of Communication. It is an implicit answer to a double question: i) what makes a communicational discourse be „philosophy” and ii) what accurately individualizes the philosophical discourse, making from a text „a philosophical text”, a philosophical discourse, a philosophical message? Results that:\n 1. essential in the philosophical communication, as well as in any other type of communicational discourse, it is not the producer but the nuclear message which he succeeds in transmitting and co-constructing meanings together with his recipient;\n 2. the distinctive feature of the philosophical communication, of the philosophical discourse, of the philosophical text as a communication practice is the discursive approach of the philosophemes, the „philosophematic” message.

ABSTRACT -AIMS: Survivin is a member of the inhibitor of apoptosis protein (IAP) family; it is overexpressed in most cancer tissues and induces resistance to radiation therapy. In this study, we investigated whether knockdown of survivin by siRNA can induce apoptosis and enhance radiosensitivity in oral squamous cell carcinoma cells (OSCC).\nMATERIALS AND METHODS:Oral squamous cell carcinoma cell lines KB was subjected to radiotherapy. small interfering RNA (siRNA) targeting survivin was transfected into KB cells in vitro,then subjected to radiotherapy.After irradiation or/and siRNA transfection, viable and dead cells were counted to determine radiation sensitivity by MTT assay, proliferation by colony-forming ability and apoptosis was analyzed by flow cytometry. Tumor-bearing mice were irradiated with 6 Gy of 60Co-γ radiator. \nRESULTS:The results showed knockdown of survivin in KB cells showed reduced cell proliferation, an increased number of radiation-induced apoptosis. Apoptosis was increased by knockdown alone and increased further in combination with irradiation. Colony formation was significantly reduced by survivin knockdown in combination with irradiation.\nCONCLUSIONS: We then conclude survivin down-regulation sensitizes cells toward irradiation. Survivin knockdown in combination with radiation inhibits cell proliferation and colony formation significantly and increases apoptosis more than each single treatment alone. In addition, siRNA survivin significantly enhanced inhibition of tumor growth and potentiated cell apoptosis by irradiation in KB xenografts. In conclusion, down regulation of survivin could enhance sensitivity of human KB cells to radiotherapy in vitro and in vivo.

Bronchofree capsule composed of four components which are diphenhydramine HCl, benzonatate, guaifenesin and phenylephrine HCl in the ratio of 2.5:10:10:1 respectively. Their UV absorption spectra show severe overlap which prevents their simultaneous determination by classical methods of analysis. Literature review showed only one reported HPLC method. PLS-1 method which is one of the most powerful chemometric methods was used for resolving this quaternary mixture. Chemometric methods generally uses theories and methods developed in mathematics, statistics, computer science and other disciplines to extract usful informations from chemical data and to relate many variables to concentrations of the analytes. Another method depends on wavelength selection for PLS-1 using geneic algorithm (GA-PLS) was used for analysis of this mixture. A calibration set consisting of 16 samples containing different ratios of four components was used for constructing models of two methods. A validation set consisting of 6 mixtures was used to validate the prediction ability of these models with mean percentage accuracy for DP by PLS-1 was 100.72 ± 2.07, for BN, GU and PH by PLS-1 and GA-PLS were 99.91 ± 1.65 and 99.91± 1.51, 101.00 ± 1.44 and 100.98 ± 1.02, 98.84 ± 1.22 and 99.39 ± 1.23 respectively. The proposed methods used to quantify components in bronchofree capsules with no interference of the additives as propylene glycol and poly ethylene glycol added so no need of preliminary extaction of analytes from dosage form. PLS-1 and GA-PLS allowed rapid, accurate, precise and simple methods for simultaneous estimation of the concentration of the analytes of interest in synthetic laboratory mixture and in commercial pharmaceutical preparation without any interfence from excipients.

Abstract\nAim:The Y-chromosome azoospermic factor (AZF) regions include genes whose specific roles and functions in spermatogenesis have not been completely clarified. Hence, recognition of the association of AZF microdeletions with male infertility has suggestions for the diagnosis, treatment and genetic counseling among infertile patients. Material and Methods:On the basis of cytogenetic evaluation a total of 94 infertile males with non-obstructive azoospermic and aged 24 to 53 years were selected for this study. Molecular AZF screening technique was performed on the genomic DNA from peripheral blood samples. Weused MultiplexPCR and fourdifferentsetsof sequence-tagged sites (STS) fordetectingthemicrodeletionsinY-chromosomalAZFregionandtheY specific sequences. \nResults:Among the 94 infertile men, a total of 48 cases (48/94, 51.06%, P< 0.01) were found to have deletions in the regions of AZFb, AZFc and AZFd. Of the48azoospermicsubjectsharbouringYchromosome microdeletions,twelvehaddeletionsinAZFb,twentyinAZFc,six in AZFb+c, two in AZFb+c+SRY, two in AZFc+d, two in AZFb+d, two in AZFb+SRY and twoinAZFb+c+dregions. From the Conclusion:results, Y chromosome microdeletions analysis recommend as an important molecular test among infertile males to obtain reliable genetic information before the administration of assisted reproductive techniques and will help decrease the cost and technical difficulty of the procedure.

Abstract\nY chromosome microdeletions are a mainly important reason of spermatogenetic impairment in males. Intrachromosomal recombination actions in large homologous repetitive sequence blocks are caused these microdeletions in spermatogenesis locus azoospermia factor (AZF). We obtained the literature by the PubMed and Google Scholar. The search keywords were azoospermia factors, microdeletions and male infertility. In this review, we selected the articles published in recent years about Y chromosome microdeletions that investigated their association with male infertility. The full texts of the appropriate articles were evaluated and a total of 82 articles were used. According to the results of reviewed articles, deletions in azoospermia regions eliminate one or more of the important genes and cause serious testiculopathy that are principal in male infertility. Our study indicated that Y chromosome microdeletions is variable in various population; these data propose that other genetic, epigenetic, nutritional and/or local factors are responsible for impairments in men fertility parameters observed in different populations

Iranian traditional houses have a kind of internal spaces structure on the basis of religious and traditional ideas of the Iranian families. Spatial flexibility, legibility, introversion, spatial hierarchy and respecting family privacy have special position in architecture of Iranian houses which has been replaced by extravert architecture. Traditional architecture which has all necessary spaces for any kind of communication inside the house has been replaced by the\ninn architecture of which residents don’t expect stability and tranquility. For these residents, only equipments and services of the inn are important and they are not attached to its entirety. Living in contemporary houses has caused problems such as decrease of attachment feeling, tranquility and emergence of emotional and family problems. This article tries to compare architectural plans of Iranian traditional houses with the contemporary houses by studying\nthem and emphasizing on their space quality and richness to take effective step for inclusion of these forgotten concepts in the single- dimension spaces of the contemporary houses while introducing spatial concepts of these houses.